I thought it would be neat to sync my Video iPod with my Flickr pics. In order to do this, I found a couple tools that download your Flickr pics locally. Flickr Backup has a very nice interface and more features, but wasn't 100% reliable for me. I decided to use FlickrDown -- it's barebone, but worked.
Both these tools create subfolders for each photoset. So I have a folder called "Flickr" and have the tool create the subfolders and populate them with the photos. From iTunes, I just point to the "Flickr" photo and -- voilĂ -- Flickr on your iPod!